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Research & Development


IIT Indore envisages the process of convergence of traditional disciplines as the key to accomplish the previously unimaginable. With this foresight, IIT Indore has been promoting multi-disciplinary research programme, focusing on basic and applied research, technology development and innovation. It is this vision that has helped the institute to do very well in all spheres of science, engineering and humanities and social sciences.

 

A core competency of IIT Indore is research driven academic programme as it forms a core component of the undergraduate and postgraduate teaching. At IIT Indore, we have consciously promulgated the idea of involving undergraduate students in forefront research projects. This led to the initiation of a formal undergraduate research scheme entitled, "Promotion of Research and Innovation for Undergraduate Students".

Latest @ R and D


Research at IIT Indore has been recognized at international level with active participation in several key international projects and several joint collaborations with research organizations in Japan, South Korea, Russian Federation, Portugal, France, Germany, USA, and many other countries. The institute has been successful in securing 82 externally sponsored research projects worth over Rs. 22 Crores.

 

IIT Indore recognizes that encouraging entrepreneurship for technology development, economic and social stability is need of the hour. The Innovation and Entrepreneurship Development Centre (IEDC) at IIT Indore was started with the same vision. IIT Indore students are in the process of having their own start-ups thus applying innovation into practicality for the benefit of all. In the coming years, IIT Indore will develop into a world class centre for higher academic and industrial research and innovation.


RESEARCH HIGHLIGHTS

Title : Targeting G-quadruplex for cancer

In structural biology lab, we have been working on elucidation of structural and molecular basis of Drug-Nucleic acid interactions. In this context we have studied the interaction of small molecules of natural origin readily available in human diets with G-quadruplex DNA formed at various regions of human genome like telomeric DNA, promoter region of various proto-oncogenes such as c-myc, c-kit21, bcl2, etc. These genes are known to be involved in development and progression of various cancers. First of all, we have studied the interaction of flavonoids with G-quadruplex DNA formed by human telomeric DNA sequence. By employing detailed biophysical techniques like Circular Dichroism (CD), UV-Visible, steady state, and time resolved fluorescence spectroscopy, we have probed these interactions. Further, the structural basis of this interaction and we have reported the first solution structure of the complex formed by Quercetin and G-quadruplex DNA formed by human telomeric DNA sequence. Furthermore, we have explored the mechanism for anticancer activity of flavonoids.

 

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Research highlights from Discipline of Chemistry

 

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